Publications > Diabetic Wounds

MolecuLight® improves success with
Diabetic Wounds

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A listing of key peer reviewed research featuring MolecuLight®
100+ peer-reviewed publications

Diabetic Wounds

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Diabetic Wounds, Species Detected, Biofilm & Other Preclinical Studies

Assessing Biofilm at the Bedside: Exploring Reliable Accessible Biofilm Detection Methods

Mayer, P et al. Diagnostics 2024

Fluorescence imaging demonstrated superior sensitivity (84%) and accuracy (63%) compared to clinical signs of biofilm (sensitivity 44% and accuracy 43%) and biofilm blotting (sensitivity 24% and accuracy 40%).

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Diabetic Wounds, Outcomes & Cost Effectiveness

The Use of Point-of-Care Bacterial Autofluorescence Imaging in the​ Management of Diabetic Foot Ulcers: A Pilot Randomized Controlled Trial

Rahma, S. et al. Diabetes Care 2022

RCT evidence that MolecuLight imaging dramatically improved DFU healing outcomes. Wound healing rates doubled at 12-weeks (45% vs. 22%) and the presence/absence of bacterial fluorescence reliably predicted the degree of wound closure.

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Diabetic Wounds, Outcomes & Cost Effectiveness

Routine fluorescence imaging to detect wound bacteria reduces antibiotic use and antimicrobial dressing expenditure while improving healing rates: Retrospective analysis of 229 foot ulcers

Price, N. et al. Diagnostics 2020

A “before and after” cohort study showing that fluorescence imaging reduced antibiotic and antimicrobial dressing needs and wound care costs while improving foot ulcer healing rates (39% to 48%).

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Diabetic Wounds, Validation

Point-of-care fluorescence imaging reveals extent of bacterial load in diabetic foot ulcers

Armstrong, DG et al. Int Wound J 2023

This study reveals the limitations of relying on clinical signs and symptoms for detecting harmful bacteria in DFUs. The concept of “chronic inhibitory bacterial load” (CIBL) is introduced, with MolecuLight imaging vastly improving its detection for better wound care.

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Diabetic Wounds, Validation

Use of a bacterial fluorescence imaging device: wound measurement, bacterial detection, and targeted debridement

Raizman, R et al. J Wound Care 2019

Wound measurement accuracy was validated at >95% using the MolecuLight i:X device,​ and fluorescence imaging before and after standard debridement revealed persistence​ of bacterial fluorescence in 100% of DFUs.

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Diabetic Wounds, Validation

Point-of-care fluorescence imaging predicts the presence of pathogenic bacteria in wounds: a clinical study

Rennie, MY et al. J Wound Care 2017

MolecuLight-guided curettage or biopsy sampling positively predicted bacterial presence in wounds at potentially harmful levels, entirely eliminating the risk of false negative sampling.

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Diabetic Wounds, Sampling & Antimicrobial Stewardship

Improved detection of clinically relevant wound bacteria using autofluorescence image-guided sampling in diabetic foot ulcers

Ottolino-Perry, K et al. Int Wound J 2017

MolecuLight-targeted sampling demonstrated superior accuracy versus Levine swabbing in detecting high bacterial loads, also identifying a greater diversity of bacterial species within wounds.