aUniversity Health Network, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada. bUniversity of Toronto, Department of Medical Biophysics, Faculty of Medicine, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada. cUniversity Health Network, Department of Biostatistics, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada. dUniversity of Toronto, Dalla Lana School of Public Health, 155 College Street, 6th Floor, Toronto, Ontario M5T 3M7, Canada. eUniversity Health Network, Techna Institute, 124-100 College Street, Toronto, Ontario M5G 1P5, Canada.